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Bullet momentum means a LOT more than kinetic energy, and throwing big pills at game is a great way to put a hole in them. I'm a guy that has hunted a lot with "big and slow bullets," whether in leverguns or revolvers, as well as tinkering with them in subsonic loadings. So if you survive those consequences, then the ballistics are the next determinant factor for me. There just aren't that many bullets on the market made to expand at super slow velocities. Often, the heavier pills in a given caliber are designed around "standard" or "magnum" cartridges, such that they are NOT designed to expand at sub-sonic velocities. Bullet design for short ogive "fat" bullets made for sub-sonic work means crappy BC's, relatively.Chamber throat and magazine length limitations can steal a lot of powder capacity from a round.A 150grn 300Blk at 2000fps needs a different twist than a 230grn pill at 1,000fps.
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It's REALLY hard to have your cake and eat it to. Twist rates for "standard loads" are different than that of twist rates for sub-sonic loads.These are a few things that you have to live with, even before the bullet gets out of the muzzle: The larger problem that I have found with sub-sonic ammo isn't about what the ballistic tables say - it's about the physical limitations of the rifles and cartridges themselves.